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KMID : 0360319930250060935
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Journal of Korean Cancer Research Association
1993 Volume.25 No. 6 p.935 ~ p.940
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A Calinical Study with Pirarubicin in the Advanced Breast Cancer
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오승택
정상설/신종태/김인철/김의동
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Abstract
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Adriamycin is regarded as one of the most active anticancer drug in the avanced breast cancer. But its usefulness is limited by its well known side effect. Pirarubicin, is one of new anthracyclin derivative, suggested less cardiac toxicity and
favorable
therapeutic efficacy.
For the clinical assessment of the efficacy and toxicity of pirarubicin. We treated 25 patients in advanced or metastatic breast cancer with pirarubicin at 21 day interval for at least 3 cycles or until the development of progressive disease.
The median age was 42 years old and 12 patients were premenopausal.
Twelve patients had prior chemotherapy and ten had hormonal therapy.
There is 24% overal response by pirarubicin but no complete response case is observed.
Such side effects as leukopenia and gastrointestinal disturbances were observed but alopecia was mild and no cardiotoxicity was seen in any of the patients. Hepatorenal function is not affected by pirarubicin.
With the above clinical results in this short term trial, pirarubicin has less toxicity than adriamycin and the acceptable therapeutic effect in the advanced breast cancer.
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KEYWORD
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